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Pharmacology offers parallels

The purinergic receptor family, including P2Y 12 (involved in microglial chemotaxis) and P2X 7 (which activates the inflammasome), is also being actively investigated as a potential pharmacological target [488, 489]

An upregulated expression of CBS has been observed in hydrogen peroxide-exposed human and porcine lenses, indicating that oxidative stress can upregulate the transsulfuration pathway to trigger the conversion of homocysteine to cysteine for glutathione production

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Funding The study was supported by a Start-Up Grant from University Grants Commission (UGC) Grant No