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These epigenetic modifications contribute to the long-term cardioprotective effects of SFN [150]

doi: 10.1016/j.xcrm.2023.101254 80 ShahbazSBozorgmehrNLuJOsmanMSliglWTyrrellDLet al

Conversely, overexpression of GCLC reversed these effects (Fig

Structural, biochemical, cellular, and functional changes in skeletal muscle extracellular matrix with aging

10.1111/jocd.12143 98 IbrahimiO

The mechanism involves upregulation of VEGF expression a key growth factor in new blood vessel formation and activation of ERK1/2 signaling pathways that drive cell proliferation, migration, and angiogenesis