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Hypoxia and high-altitude adaptation promote the expression of genes related to oxygen homeostasis and antioxidant defense by upregulating HIFs

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Cellular redox homeostasis depends on the balance between the generation and elimination of ROS by several enzymes and antioxidants, and the imbalance of cellular redox homeostasis leads to oxidative stress, which imposes a substantial burden on cells [29, 30]

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Whereas ALA is extremely important in protecting neural tissue, CoQ10 is extremely important in protecting cardiac and vascular tissue

Weschawalit S et al