Additionally, we analyzed postmortem human brain tissue with histopathologically confirmed AD or progressive supranuclear palsy (PSP), an age-associated tauopathy that clinically manifests as parkinsonism with additional motor abnormalities and cognitive dysfunction, and is neuropathologically defined by NFTs, gliosis and neurodegeneration (104)
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In the apo structure of IGF1R, only the N-terminal portion of -CT (residues 682704) adopts a short -helix, while the rest of this motif is disordered 7
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