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Diarrhea is one of the most commonly reported side effects in retatrutide clinical trials, affecting anywhere from 9% to 35% of participants depending on dose level and study phase

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Tirzepatide works on two hormone pathways instead of one, which may lead to stronger appetite suppression for some patients

Thats why an evaluation by a gastroenterologist is crucial

GeroScience 46(2):2697

Current evidence does not show that GLP-1 medications directly cause thyroid nodule formation or rapid nodule growth in patients without a personal or family history of medullary thyroid cancer