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Meanwhile, cryo-EM structures of ABCC1, CFTR, and Ycf1 reveal a mostly disordered R-domain 22,23,24 without assigned sequence for the phosphorylation sites, limiting our understanding of R-domain interactions

Animal studies show low acute toxicity, but human safety data remain limited,,

Among the combination therapies, the SGLT2i-preceding group showed a significant reduction in annual eGFR decline, while the GLP1Ra-preceding group did not

Saneto, RP, Cohen, BH, Copeland, WC, Naviaux, RK 2013, Alpers-Huttenlocher Syndrome, Pediatric Neurology , vol

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