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Increased blood glucose concentration induces an increase in the production of a polypeptide hormone called insulin (90, 91)

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Patients with type 2 diabetes were assigned to one of three treatment cohorts: metformin alone, GLP-1 receptor agonist alone, and dual metformin + GLP-1 RA therapy, each compared against a referent group receiving DPP4 inhibitors (DPP4i)