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However, their dysfunction, marked by impaired oxidative phosphorylation, excessive oxygen species (ROS) production, and defective quality control, disrupts these processes and causes cellular and organ damage

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In whole-cell current clamp experiments, hyperpolarizing or depolarizing current pulses (500 ms, from 10 to 30 pA in 5-pA steps) were injected into neurons to determine input resistances or trigger action potentials