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These free radicals can be anything from UV exposure, everyday stress, alcohol, and more

Diclofenac, however, like all drugs that inhibit prostaglandin synthesis interfere with platelet function to some degree

So, is there a concern about overdose

This is because intravenous administration bypasses the digestive system, allowing for quicker absorption at higher concentrations

Thus, regulation of mitophagy may be a valuable therapeutic option that targets the elimination of dysfunctional mitochondria while still providing sufficient energy to mitigate cellular damage, restore protein translation, and ultimately restore homeostasis ( FIGURE 1 3 Overview of mitophagy Mitophagy is a mitochondria-specific form of autophagy that selectively degrades damaged mitochondria through receptors (Figure 2)