( CYP24A1 ) is involved in the catabolic inactivation of 1,25(OH) 2 D 3 and its inhibition is thought to limit 1,25(OH) 2 D 3 signaling (39)
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122 Therefore, Nrf2 activation is an important therapeutic target in cancer management
clearing the confusion"
Our findings fill this gap by demonstrating that reduced GCLC expression precedes and potentially drives the loss of GSH, leading to a cascade of oxidative stress, mitochondrial dysfunction, and neuronal apoptosis
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