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Treatment also improved motor activity and increased BDNF, which promotes neuroplasticity and protection [108]
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Additionally, they inhibit the secretion of glucagon, a hormone that raises blood sugar levels, and slow gastric emptying, leading to a prolonged feeling of fullness and reduced appetite
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The added thermogenic and hepatic-lipid effect is hypothesised to account for the larger weight-loss magnitude observed in Phase 2 compared with dual GIP/GLP-1 agonism [1]
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