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NAC suggests being one possibility connecting earlier hypothesised concepts of depression, and many of its effects could be related to this compounds antidepressant effects

So far, clinical trial data for elamipretide and bardoxolone underscore the viability of mechanism-driven therapies in treating OSrelated diseases ( Evidence about the role of mtROS has led to the development of MATs for therapeutic intervention in several diseases, including HTN -Figure 2 (Pool et al., 2021), whereas MitoTEMPO can scavenge mtROS, reduce oxidative damage to mitochondria, restore mitochondrial function, and help maintain normal cellular function ( 5.3 NADPH oxidases (NOXs) NOXs are the only known enzymes specifically responsible for generating ROS (Ogrunc et al., 2014)