GLP-1 receptor agonists improve liver enzymes primarily through indirect mechanisms including enhanced insulin sensitivity, reduced hepatic fat accumulation, weight loss, and decreased inflammatory cytokine production
As weight decreases and energy improves, physical activity becomes easier and more appealing, creating a positive feedback loop
[DOI] [PubMed] [Google Scholar] 93.Marrano N., Biondi G., Borrelli A., Cignarelli A., Perrini S., Laviola L., Giorgino F., Natalicchio A
Healthy fats appear in moderation Fat is essential for nutrient absorption, hormone production, and satiety
These considerations highlight the need for future studies specifically designed to evaluate GLP-1RAs in patients at high risk of PsA, particularly those with subclinical inflammation or early musculoskeletal symptoms
Current evidence from randomised controlled trials, meta-analyses, and real-world studies indicates no consistent or causal relationship between these agents and serious GI side effects
