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copri intervention, mediated through gut barrier repair, significantly restores bone homeostasisincluding enhanced bone density and bone remodeling balanceand promotes osteoblast ferroptosis resistance in both in vitro cellular models (e.g., MC3T3-E1 cultures) and in vivo animal models (e.g., OA mice) (Li et al., 2025)

Theres a rebound effect that goes far beyond weight and Al-Aly says that there is a danger that could put people at risk of cardiac events

maintaining the same weights week over week is not enough to signal preservation

She essentially created a calorie deficit with activity

Because it contains oxygen