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10.1002/dmrr.3464 67 KrentowskaA.ebkowskaA.Jacewicz-wickaM.HryniewickaJ.LeniewskaM.AdamskaA.et al (2021)

They want to know if timing matters and what to do about it

Keep tightly closed in a cool, dry place away from direct sunlight and heat

Moverare-Skrtic S, Svensson J, Karlsson MK, Orwoll E, Ljunggren O, Mellstrom D, Ohlsson C: Serum insulin-like growth factor-I concentration is associated with leukocyte telomere length in a population-based cohort of elderly men

This is most likely mediated via a humoral route based on increased availability of its precursor tryptophan in the plasma [231]

Thus, thiamine, combined with other vitamins of the B complex such as B2 and B3, is vital for the proper functioning of various enzymes involved in key biochemical processes, primarily those related to energy production (34, 36) ( Figure 3 )