No human safety data : The complete absence of human clinical trials means the safety profile, side effects, optimal dosing, and pharmacokinetics in humans are entirely unknown Animal-to-human translation is uncertain : Metabolic differences between mice and humans mean that the magnitude of effects (e.g., weight loss, grip strength improvement) may not translate
This route of delivery means the full dose is available to the body immediately, without the absorption variables that can affect oral supplementation
Vitamin shots like B12, as well as other energy or diet supplements containing strong stimulants, then became all the rage among housewives and celebrities alike
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The limitations of this work are that we included RCTs, non-RCTs, and observational studies, which may lower the overall quality of evidence of the included studies
Being water-soluble, the effects of vitamin B12 can take place immediately when administered through injections
