It works by waking up the cells at the base of hair follicles and boosting collagen production, which is why it's being studied for regrowing hair and rejuvenating skin
doi:10.1016/j.jamda.2016.09.010
Below is a clinicians view of why it happens, what counts as normal, and the warning signs that mean you should stop waiting it out and speak to a doctor
Comparison Table: AHK-Cu vs
Reasons for fatigue Fatigue stems from physical or mental factors, including things like: Metabolic conditions such as diabetes, kidney disease, Cushing syndrome, and thyroid conditions Mental health issues such as depression, stress, eating disorders, anxiety, and burnout Cardiovascular conditions affecting blood flow, such as arrhythmias, heart disease, and heart failure Medications such as antidepressants, antihistamines, steroids, statins, and sedatives Sleep problems due to insomnia, narcolepsy, jet lag, and sleep apnea Chemical imbalances due to too little or too much of various essential nutrients, vitamins, and minerals Facts about B12 deficiency Also referred to as cobalamin deficiency and named after the scientific term for this water-soluble nutrient, a B12 deficiency can result from low dietary intake or from your body not absorbing the vitamin properly

One compound gaining attention is 5-Amino-1MQ, an investigational molecule being studied for its potential effects on NNMT activity, fat cell metabolism, insulin-related pathways, and broader metabolic health