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However, of this cohort with improved EF, 41% had a recurrent decline in LVEF (EF 40%) over a median follow-up of 11 years 18

Of these people, many have other serious chronic illnesses, like high blood pressure or diabetes

Br J Pharmacol 179(4):557570 Tuttle KR, Lakshmanan MC, Rayner B, Busch RS, Zimmermann AG, Woodward DB et al (2018a) Dulaglutide versus insulin glargine in patients with type 2 diabetes and moderate-to-severe chronic kidney disease (AWARD-7): a multicentre, open-label, randomised trial

Both the improvement of metabolic parameters (blood glucose, insulin-resistance, lipids) and the loss of body weight related to GLP-1 RAs use suggest a role of these drugs in the management of metabolic liver diseases [1315]

On the other hand, semaglutide, a single-action GLP-1 agonist, provides better appetite control and weight loss compared to metformin, with an average weight loss of 12.4% at its maximum dose