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It doesnt get much attention in functional medicine circles, and it gets almost none in the optimization or muscle-building conversation

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However, preclinical studies demonstrate therapeutic effects with once-daily or even less frequent administration, suggesting tissue distribution, receptor binding, or cellular signaling effects extend beyond plasma clearance

Missailidis D, Sanislav O, Allan CY, Annesley SJ, Fisher PR

Hotels and resorts are leaning in with blackout curtains, circadian lighting, smart beds, and guided wind-down routines

J Clin Invest 113 : 96105 Clemmons DR et al