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Biomedicine & Pharmacotherapy, 166 , Article 115301

Receptor Desensitization IGF-1 LR3 has a long half-life , which means continuous exposure can reduce the sensitivity of IGF-1 receptors over time

Damaged intestinal barrier can facilitate the development of local diseases such as irritable bowel disease, inflammatory bowel disease or celiac disease, but also the development of systemic inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, hepatitis, and lupus erythematosus, neurodegenerative or psychiatric conditions, or metabolic diseases such as diabetes or obesity

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