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As mitochondria fail to maintain cellular energy, neuronal survival is compromised, and apoptotic pathways are activated (Davidson et al., 2001) (Figure 1)

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There are a number of methods to reduce the out-of-pocket cost of these drugs, including subsidies and increasing insurance coverage, but Govind Persad of the University of Colorado Law School noted that it is also critical to ensure that incentivesmany of which are monetaryremain for drug developers to continue to innovate in this field while simultaneously maximizing patient access now