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Collagen levels naturally decline in the mid-20s

(PubMed) Keith DJ, Butler JA, Bemer B, et al

That alone would be noteworthy, but the anti-inflammatory story doesnt stop there

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Under oxidative stress, excessive ROS such as OH directly attack DNA, causing single-strand or double-strand breaks, activating PARP-1, consuming NAD and ATP, and generating poly(ADP-ribose), resulting in mitochondrial membrane potential loss and the release of apoptosis-inducing factor, ultimately resulting in cell death [252]

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