The oral semaglutide landscape is evolving, with multiple formulation approaches competing for attention
The clear influence of therapeutic GLP-1 analogs on the physiology of the digestive system as well as the stability and diversity of the gut microbiota deserves special attention because disorders of the gut-brain axis homeostasis also appear to be an important, although so far somewhat understudied factor, which may lead to the development of depression
A more serious risk associated with GLP-1 drugs is low blood sugar levels (hypoglycemia), particularly when taken in conjunction with other blood sugar-lowering medications like sulfonylureas or insulin
doi: 10.1177/1060028017689878 64 Pharmacological profile, efficacy and safety of lixisenatide in type 2 diabetes mellitus
Considering the widespread expression of GLP-1 receptors in the brain, the authors recommend that future studies should focus on identifying the key neurocircuits involved in mediating the effects of GLP-1 receptor agonists on substance use disorder, as well as determine the specific patient subtypes who are most likely to benefit from these treatments
This happened long before any blood glucose could be detected
