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These immune-mediated events were compounded by intolerable gastrointestinal side effects, including nausea in 59% and vomiting in 37% of participants, along with reports of acute pancreatitis, culminating in a dropout rate of 2634% in Phase 3 trials [65]

Fatigue : A feeling of tiredness or low energy is another common side effect

86% of participants on 12 mg achieved a liver fat content below 5%, which is the threshold for normal [8]

The effects on appetite and feelings of fullness were measured

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For research purposes, this is a reason for further investigation, not a reason to dismiss the signal