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doi: 10.1038/s41586-020-2474-7 189 RosenbergHJRaoM

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However, in sheep, reducing ZP thickness had no significant effect on the hatching of the embryos (Mousavi et al., 2022)

The preclinical safety information for Wegovy adds: In developmental toxicity studies in rabbits and cynomolgus monkeys, increased pregnancy loss and slightly increased incidence of foetal abnormalities were observed at clinically relevant exposures. While the company is now carrying out trials to explore whether such drugs are safe for pregnant women, at present it advises that semaglutide should not be used during pregnancy as it is not known if it may affect an unborn child

The BALANCE model is designed exclusively for Medicare and Medicaid beneficiaries