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131 Although GLP-1Rs are present, they are limited in number, making the direct inhibitory effect of GLP-1 on -cells relatively weak

The incidence of type 2 diabetes has also been rising throughout the world in the past decades, with this trend of increase stabilizing and even reversing in some populations only in the last 20 years (Magliano et al., 2019)

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The Fab7F38-bound GLP-1R is crystallized in a closed conformation with the ECDs peptide-binding area sealed, in line with the non-competitive property of Fab7F38

GLP-1 Receptor Glucagon-like peptide 1 receptor (GLP-1R) is a G-Protein coupled receptor found on the cell membranes of pancreatic and other cells