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Gradual titration (dose escalation) leads to better tolerability

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Well, the existing data do not show that. Patients often stop using GLP-1s within a year for a variety of reasons, including cost, meeting their goal weight or gastrointestinal side effects

In brief, all of the mechanisms and actions that have protective efficiency on endothelium and VSMCs, can play a role in preventing vascular senescence (Figure 2)

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