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Increased oxidative stress causes ion channel opening as well as oxidative damage to cellular components such as lipids, proteins, and nucleic acids [6]

Furthermore, ER stress is acknowledged as a secondary consequence of metabolic dysfunction, frequently caused by the excessive buildup of reactive oxygen species (ROS) and disruptions in intracellular calcium levels

Further, GSH is described to buffer endogenous electrophiles 77,78

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doi: 10.1111/bph.15191 219 WeiX.NishiT.KondouS.KimuraH.ModyI

cerevisiae , the MAPK cascade regulates cell wall biosynthesis, a key determinant of cell morphology, as well as the overall cell cycle