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Melatonin acts on oscillators according to a well-defined phase-response curve (PRC)

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Mice with ghr Box1 deletion by substitution of each proline in the Box1 to alanine (which eliminates JAK2 binding and signaling, while still allowing signaling to occur via the SFKERK1/2 pathway) have obstructed growth with a similar phenotype observed in mice with ghr KO (109, 110)