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- Most evidence comes from animal studies - Human data is extremely limited - No FDA approval for orthopedic use - Clinical benefit in musculoskeletal conditions remains unproven While the biology is interesting, potential does not equal proven clinical outcomes

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Some claim pre-workout dosing enhances performance and protects tissues during training

doi:10.1371/journal.pone.0068331

doi: 10.1007/s00425-004-1430-3 13 DelaneyT