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Carotenoids, inflammation, and oxidative stressimplications of cellular signaling pathways and relation to chronic disease prevention

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287,487 Furthermore, FAO inhibitors such as CPT1A inhibitors have demonstrated efficacy in impairing CSC survival, particularly in hypoxic TMEs where CSCs rely on FAO as an alternative energy source

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Patients with homozygosity at this mutated locus tend to exhibit a more severe clinical phenotype, usually associated with severe mental retardation and early onset seizures, and five of them died early in life [6,7,8]