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Users are essentially participating in uncontrolled self-experimentation, a reality that informed decision-making requires acknowledging

When drugs did emerge, the story was predictable: an early wave of excitement followed by disappointment, safety scandals, or regulatory withdrawal

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Opioids Opioids are drugs that can be prescribed by doctors to treat pain, such as oxycodone (OxyContin), hydrocodone (Vicodin), morphine (Arymo), and methadone (Dolophine), according to the Centers for Disease Control and Prevention (CDC)

doi: 10.1038/s41467-020-16274-w