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A subsequent combined analysis of the STEP 14 studies showed that gastrointestinal adverse events (nausea, vomiting, diarrhea, and constipation) were more common with SMG than with placebo but typically mild to moderate and transient, with weight loss being largely independent of gastrointestinal adverse events [103]

A 68-week clinical trial found that middle-aged adults with obesity who took weekly injections of Wegovy lost an average of 35 pounds, while participants in the control group only lost an average of 6 pounds

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