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Shaking the vial to dissolve creates foam and shear stress 4

B vitamins play a role in metabolism, hematopoiesis, and nervous system function, with benefits that can be cumulative over time

Documented best practice for sealed vials: A cool, dry location at room temperature, protected from direct light, in the original manufacturer carton if possible

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SAM is a methyl group donor for numerous methylation reactions in the brain, including those involved in the metabolism of neurotransmitters whose deficiency has been related to depression (102)