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J Neuropathol Exp Neurol 57 (4), 338342

Aging manifests as a highly complex, temporally evolving process driven by interconnected molecular pathways, rendering monotherapies, such as senolytics, insufficient to achieve comprehensive phenotypic reversal

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473 BRD4 Bromodomain-containing protein 4 (BRD4) mediates its role as transcriptional co-activator by acting both as a passive scaffold to promote recruitment of transcription factors and as an active kinase to phosphorylate RNA polymerase II, thereby regulating transcription

Drink lots of fluids (water) at least 2 litres per day and especially for the first 24 hours