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However, following weekly administration, B12 levels declined to a median of 530 pmol/L after 90 days

Sadgrove NJ, Simmonds MSJ

The elderly (reduced absorption) Pernicious anemia Vegetarians / Vegans (low dietary B12) People taking metformin or acid reflux medications (PPIs) Post-bariatric or gastric-bypass patients Genetic variants in MTRR , MTR , or TCN2 What Has B12 Been Studied For

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It may deplete the body of glutathione (to cleanse the cyanide molecule attached to it), which the body needs to lower the high homocysteine levels prevalent in PA