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VAN DUUREN, B.L., ORRIS, L., & NELSON, N

The parallel Ras-Raf-MEK-ERK1/2 arm (ERK Thr-202/Tyr-204 phosphorylation +1.2-1.4 at 15-30 minutes) drives myoblast proliferation (BrdU +28-34%) via cyclin D1 upregulation and Rb phosphorylation

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The result at week 68: Continued semaglutide 2.4 mg: lost an additional 7.9% of body weight (total loss from baseline: 17.4%) Switched to placebo: regained 6.9% of body weight (net loss from baseline: 5.0%) Thats a roughly 15-point difference in body weight between the two groups at the end of the trial, attributable entirely to whether the medication continued