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This reaction is catalyzed by mitochondrial 1-hydroxylase (CYP27B1), producing 1,25-dihydroxyVitamin D [1,25(OH)D], the biologically active form of Vitamin D [94, 95]

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In approximately half of patients the course of the disease is complicated by the formation of fistulas, intra-abdominal abscesses, and intestinal strictures (1, 2)