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Some protocols combine both, but this should only happen with medical supervision.

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A study in 49 people with knee osteoarthritis found that taking 3.4 grams of MSM per day for 12 weeks reduced pain and stiffness and improved physical function, compared to a placebo ( Additionally, it can enhance the effectiveness of other common supplements used to treat arthritis such as glucosamine sulfate, chondroitin sulfate and boswellic acid

Rubenstein & Merzenich, 2003) involving either or both upregulated glutamatergic excitatory and down-regulated GABAergic inhibitory systems(Sohal & Rubenstein, 2019)

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In both studies, a single subcutaneous injection given once every three months produced median triglyceride reductions of 79 and 81 percent respectively at 12 months, compared to roughly 27 percent with placebo