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doi:10.3390/cosmetics2030236 Pickart L, Vasquez-Soltero JM, Margolina A

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Notably, the recent endometrial organoids represent only the epithelial fraction and lack the full complexity of endometrial stromal cells, vascular components (endothelial cells) and immune cells

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Preclinical research raises concerns about overstimulating growth pathways, which could increase risks such as tumor development

Third, adaptive clinical trial designs involving larger patient cohorts and multi-center validation will be crucial to demonstrate efficacy beyond preclinical promise