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MC5R: Expressed in multiple tissues, its exact physiological role remains relatively undefined, although it is believed to be involved in exocrine function

When AOD-9604 binds to or modulates these receptors, it preferentially activates fat cells while having minimal effects on other tissues that primarily express beta-1 and beta-2 adrenergic receptor subtypes

However, the comparison of NNT across various drug classes must be nuanced given the NNT values are specific to individual trial design, study population baseline characteristics, and the time of outcome measurement

10.31887/DCNS.2017.19.2/cjones 78 KarnonJ.TolleyK.OyeeJ.JewittK.OssaD.AkehurstR