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When SAMe is low, the remethylation of homocysteine to methionine is prioritized in the cell (instead of the transsulfuration pathway).[ref] Drains on methyl groups: About 40% of methyl groups are used for creatine synthesis, so when creatine levels are higher, it can reduce the need for methyl groups

The Loading Phase: For those with chronic fatigue or brain fog, we often recommend 4-6 sessions over a 3-week period to fully saturate the cells

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