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Considering that insulin is internalized in the apical membrane by a receptor-mediated endocytic mechanism, the increased urinary insulin excretion might represent a tubular dysfunction

doi:10.1042/BST0330811

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Available from: Wharton S, Calanna S, Davies M, Dicker D, Goldman B, Lingvay I, et al

Mechanism with Numbers: How IGF-1 LR3 Works IGF-1R is a heterotetrameric receptor tyrosine kinase