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[9] [10] Seek prompt medical attention if you experience: Severe or persistent abdominal pain, particularly radiating to the back (possible pancreatitis) Rapid or irregular heartbeat Signs of a severe allergic reaction including swelling of the face, lips, or throat, or difficulty breathing call 999 or attend your nearest A&E immediately Symptoms of significant dehydration (dizziness, reduced urine output) due to persistent vomiting or diarrhoea Symptoms of hypoglycaemia if taking concomitant insulin or sulphonylureas Anyone experiencing unexpected symptoms whilst participating in a clinical trial should contact their trial investigator or GP without delay

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therefore, blood glucose and plasma insulin levels have been increased but do not show any effects on the secretion of GIP

Both Ozempic and retatrutide have been tested in large, well-designed, placebo-controlled trials