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Other side effects are rare and usually mild when they do occur
Moreover, emerging evidence has shown that the SGLT2i and GLP-1RA combination therapy was associated with fewer cardiovascular events in the population with T2DM and MI, compared to either drug used alone [98]
Oral semaglutide (Rybelsus), approved in 2019, offers a non-injectable alternative (Kommu S et al., 2025)
A trial with 30 women that compared the impact of a high dose of liraglutide to metformin combined with low dose of liraglutide on weight loss showed that after 12 weeks, both treatment schedules brought considerable weight loss (6.3 3.7 kg monotherapy vs
Marginal efficacy : Even safer drugs such as orlistat achieved only modest weight loss, disappointing patients