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Phase III randomized study of second line ADI-PEG 20 plus best supportive care versus placebo plus best supportive care in patients with advanced hepatocellular carcinoma

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Continued work is essential to refine its delivery systems and assess its efficacy and safety across broader animal models, especially primates, to approximate human clinical conditions

NAD-boosting increased 4-6 fold the blood NAD + depending on individual, pointing to need of personalized dose adjustment in treatment trials