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Intravenous or liposomal forms may achieve better tissue levels, but research does not support glutathione as a standalone weight-loss therapy

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Due to irons hydrophilic properties, iron needs to traverse the BBB to enter the brain parenchyma from the circulating blood, and BBB disruption and intracranial hemorrhage in TBI patients lead to iron deposition in the brain, disrupting iron metabolism

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Safety, particularly regarding immunogenicity, constitutes another critical challenge