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If you go back to late nights, stress, fast food, or heavy drinking, those benefits can fade quickly

However, these outcomes are gradual and best measured over several months not weeks

10.1038/35037627 187 SlayterH

First, the tryptophan residue at position 1 and the peptide bonds throughout the chain are substrates for plasma peptidases, which accounts for its short half-life

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In a healthy body, an enzyme called glutathione reductase uses a specific co-factor (NADPH) to turn that spent GSSG back into the active GSH form