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The more pronounced decline in hip BMD, as compared to the relative preservation of lumbar spine BMD, is likely due to the predominance of mechanically responsive cortical bone in the hip, whereas the lumbar spine is composed largely of metabolically active trabecular bone

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This piece in 1993 also provided new insights into the biology of exendin, namely that exendin-4 was a full agonist of the human GLP-1 receptor, which Mojsov argues was crucial to convincing Amylin to develop exendin as a drug for diabetes (see below)

Clinical studies show more modest, variable results

During weight loss, its crucial to maintain muscle mass to keep metabolic rates from falling

After 6 weeks, you see minimal improvement