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For hair-specific applications, some protocols combine systemic subcutaneous GHK-Cu with direct scalp delivery via mesotherapy, injecting diluted GHK-Cu solution directly into the scalp to maximize follicle-level exposure alongside systemic administration

The cells were treated with these cocktails for 3 days, with variations in CHIR concentration and the presence of Ly or PD to optimize DE induction efficiency [1]

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This process is a key target for dietary hormetins